Scientific Reports (Jun 2024)
Aging and putative frailty biomarkers are altered by spaceflight
- Andrea Camera,
- Marshall Tabetah,
- Veronica Castañeda,
- JangKeun Kim,
- Aman Singh Galsinh,
- Alissen Haro-Vinueza,
- Ivonne Salinas,
- Allen Seylani,
- Shehbeel Arif,
- Saswati Das,
- Marcelo A. Mori,
- Anthony Carano,
- Lorraine Christine de Oliveira,
- Masafumi Muratani,
- Richard Barker,
- Victoria Zaksas,
- Chirag Goel,
- Eleni Dimokidis,
- Deanne M. Taylor,
- Jisu Jeong,
- Eliah Overbey,
- Cem Meydan,
- D. Marshall Porterfield,
- Juan Esteban Díaz,
- Andrés Caicedo,
- Jonathan C. Schisler,
- Evagelia C. Laiakis,
- Christopher E. Mason,
- Man S. Kim,
- Fathi Karouia,
- Nathaniel J. Szewczyk,
- Afshin Beheshti
Affiliations
- Andrea Camera
- Intitute of Basic Medical Sciences, University of Oslo
- Marshall Tabetah
- Department of Agricultural and Biological Engineering, Purdue University
- Veronica Castañeda
- Faculty of Medicine, Universidad de los Andes
- JangKeun Kim
- Department of Physiology and Biophysics, Weill Cornell Medicine
- Aman Singh Galsinh
- School of Medicine, Medical Sciences and Nutrition, University of Aberdeen
- Alissen Haro-Vinueza
- Biología, Colegio de Ciencias Biológicas y Ambientales COCIBA, Universidad San Francisco de Quito USFQ
- Ivonne Salinas
- Escuela de Medicina, Colegio de Ciencias de La Salud COCSA, Universidad San Francisco de Quito USFQ
- Allen Seylani
- Riverside-School of Medicine, University of California
- Shehbeel Arif
- Center for Data-Driven Discovery in Biomedicine, Children’s Hospital of Philadelphia
- Saswati Das
- Atal Bihari Vajpayee Institute of Medical Sciences, Dr. Ram Manohar Lohia Hospital
- Marcelo A. Mori
- Department of Biochemistry and Tissue Biology, Institute of Biology, Universidade Estadual de Campinas
- Anthony Carano
- Ohio Musculoskeletal and Neurological Institute, Heritage College of Osteopathic Medicine, Ohio University
- Lorraine Christine de Oliveira
- Blue Marble Space Institute of Science
- Masafumi Muratani
- Transborder Medical Research Center, University of Tsukuba
- Richard Barker
- Department of Botany, University of Wisconsin-Madison
- Victoria Zaksas
- Center for Translational Data Science, University of Chicago
- Chirag Goel
- Northwestern University Feinberg School of Medicine
- Eleni Dimokidis
- Amazon Web Services
- Deanne M. Taylor
- Department of Biomedical and Health Informatics, The Children’s Hospital of Philadelphia
- Jisu Jeong
- Translational-Transdisciplinary Research Center, Clinical Research Institute, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University
- Eliah Overbey
- Department of Physiology and Biophysics, Weill Cornell Medicine
- Cem Meydan
- Department of Physiology and Biophysics, Weill Cornell Medicine
- D. Marshall Porterfield
- Department of Agricultural and Biological Engineering, Purdue University
- Juan Esteban Díaz
- Data Science Institute, School of Business, Universidad San Francisco de Quito USFQ
- Andrés Caicedo
- Instituto de Investigaciones en Biomedicina iBioMed, Universidad San Francisco de Quito USFQ
- Jonathan C. Schisler
- McAllister Heart Institute and Department of Pharmacology, The University of North Carolina at Chapel Hill
- Evagelia C. Laiakis
- Department of Oncology, Department of Biochemistry and Molecular and Cellular Biology, Georgetown University
- Christopher E. Mason
- Department of Physiology and Biophysics, Weill Cornell Medicine
- Man S. Kim
- Translational-Transdisciplinary Research Center, Clinical Research Institute, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University
- Fathi Karouia
- Blue Marble Space Institute of Science, Exobiology Branch, NASA Ames Research Center
- Nathaniel J. Szewczyk
- Ohio Musculoskeletal and Neurological Institute, Heritage College of Osteopathic Medicine, Ohio University
- Afshin Beheshti
- Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
- DOI
- https://doi.org/10.1038/s41598-024-57948-5
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 21
Abstract
Abstract Human space exploration poses inherent risks to astronauts’ health, leading to molecular changes that can significantly impact their well-being. These alterations encompass genomic instability, mitochondrial dysfunction, increased inflammation, homeostatic dysregulation, and various epigenomic changes. Remarkably, these changes bear similarities to those observed during the aging process on Earth. However, our understanding of the connection between these molecular shifts and disease development in space remains limited. Frailty syndrome, a clinical syndrome associated with biological aging, has not been comprehensively investigated during spaceflight. To bridge this knowledge gap, we leveraged murine data obtained from NASA’s GeneLab, along with astronaut data gathered from the JAXA and Inspiration4 missions. Our objective was to assess the presence of biological markers and pathways related to frailty, aging, and sarcopenia within the spaceflight context. Through our analysis, we identified notable changes in gene expression patterns that may be indicative of the development of a frailty-like condition during space missions. These findings suggest that the parallels between spaceflight and the aging process may extend to encompass frailty as well. Consequently, further investigations exploring the utility of a frailty index in monitoring astronaut health appear to be warranted.
