Quercetin: A Potential Polydynamic Drug

Nikitas Georgiou; Margarita Georgia Kakava; Efthymios Alexandros Routsi; Errikos Petsas; Nikolaos Stavridis; Christoforos Freris; Nikoletta Zoupanou; Kalliopi Moschovou; Sofia Kiriakidi; Thomas Mavromoustakos

doi:10.3390/molecules28248141

Molecules (Dec 2023)

Quercetin: A Potential Polydynamic Drug

Nikitas Georgiou,
Margarita Georgia Kakava,
Efthymios Alexandros Routsi,
Errikos Petsas,
Nikolaos Stavridis,
Christoforos Freris,
Nikoletta Zoupanou,
Kalliopi Moschovou,
Sofia Kiriakidi,
Thomas Mavromoustakos

Affiliations

Nikitas Georgiou: Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece
Margarita Georgia Kakava: Laboratory of Organic Chemistry and Biochemistry, Department of Chemistry, University of Patras, 26504 Patras, Greece
Efthymios Alexandros Routsi: Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece
Errikos Petsas: Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece
Nikolaos Stavridis: Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece
Christoforos Freris: Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece
Nikoletta Zoupanou: Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece
Kalliopi Moschovou: Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece
Sofia Kiriakidi: Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece
Thomas Mavromoustakos: Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece

DOI: https://doi.org/10.3390/molecules28248141
Journal volume & issue: Vol. 28, no. 24
p. 8141

Abstract

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The study of natural products as potential drug leads has gained tremendous research interest. Quercetin is one of those natural products. It belongs to the family of flavonoids and, more specifically, flavonols. This review summarizes the beneficial pharmaceutical effects of quercetin, such as its anti-cancer, anti-inflammatory, and antimicrobial properties, which are some of the quercetin effects described in this review. Nevertheless, quercetin shows poor bioavailability and low solubility. For this reason, its encapsulation in macromolecules increases its bioavailability and therefore pharmaceutical efficiency. In this review, a brief description of the different forms of encapsulation of quercetin are described, and new ones are proposed. The beneficial effects of applying new pharmaceutical forms of nanotechnology are outlined.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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