A systematic review on the origin, anti-inflammatory effect, mechanism, pharmacokinetics, and toxicity of albiflorin

Abstract

Albiflorin, a principal monoterpene glycoside isolated from Paeonia lactiflora Pall., is known for its extensive pharmacological properties and medicinal value in a number of traditional Chinese medicine recipes. Herein, we consolidate current research on the biological profile, anti-inflammatory capabilities, pharmacokinetics, tissue distribution, and toxicity of albiflorin with the, aim of delineating its therapeutic potential and safety profile. Albiflorin exhibits remarkable anti-inflammatory effects in various disease models, including respiratory, urinary, gastrointestinal, and rheumatic conditions, as well as metabolic and nutritional diseases, blood system disorders, mental illnesses, and pain. Pharmacokinetic studies have revealed its efficient absorption, distribution, and elimination, indicating favorable bioavailability with minimal toxicity, as supported by traditional toxicity assessments and next-generation metabolomics analyses. Despite its proven efficacy in a broad spectrum of health conditions, comprehensive toxicological studies are scarce, highlighting the need for further research to ascertain its safety in clinical applications. This review underscores the significant therapeutic promise of albiflorin, rooted in its efficacy as the key active ingredient in relevant traditional Chinese medicine formulas and reinforced by modern scientific inquiry. Albiflorin stands at the intersection of historical wisdom and contemporary pharmacological research, warranting further exploration to harness its full medical potential, especially for the treatment of inflammation-related diseases.

Keywords

• Albiflorin
• Anti-inflammation
• Paeonia lactiflora
• Toxicity