Antibiotics (Jul 2022)
Antimicrobial Resistance in the Environment: Towards Elucidating the Roles of Bioaerosols in Transmission and Detection of Antibacterial Resistance Genes
- Paul B. L. George,
- Florent Rossi,
- Magali-Wen St-Germain,
- Pierre Amato,
- Thierry Badard,
- Michel G. Bergeron,
- Maurice Boissinot,
- Steve J. Charette,
- Brenda L. Coleman,
- Jacques Corbeil,
- Alexander I. Culley,
- Marie-Lou Gaucher,
- Matthieu Girard,
- Stéphane Godbout,
- Shelley P. Kirychuk,
- André Marette,
- Allison McGeer,
- Patrick T. O’Shaughnessy,
- E. Jane Parmley,
- Serge Simard,
- Richard J. Reid-Smith,
- Edward Topp,
- Luc Trudel,
- Maosheng Yao,
- Patrick Brassard,
- Anne-Marie Delort,
- Araceli D. Larios,
- Valérie Létourneau,
- Valérie E. Paquet,
- Marie-Hélène Pedneau,
- Émilie Pic,
- Brooke Thompson,
- Marc Veillette,
- Mary Thaler,
- Ilaria Scapino,
- Maria Lebeuf,
- Mahsa Baghdadi,
- Alejandra Castillo Toro,
- Amélia Bélanger Cayouette,
- Marie-Julie Dubois,
- Alicia F. Durocher,
- Sarah B. Girard,
- Andrea Katherín Carranza Diaz,
- Asmaâ Khalloufi,
- Samantha Leclerc,
- Joanie Lemieux,
- Manuel Pérez Maldonado,
- Geneviève Pilon,
- Colleen P. Murphy,
- Charly A. Notling,
- Daniel Ofori-Darko,
- Juliette Provencher,
- Annabelle Richer-Fortin,
- Nathalie Turgeon,
- Caroline Duchaine
Affiliations
- Paul B. L. George
- Département de Médecine Moléculaire, Université Laval, Quebec City, QC G1V 0A6, Canada
- Florent Rossi
- Département de Biochimie, de Microbiologie et de Bio-Informatique, Université Laval, Quebec City, QC G1V 0A6, Canada
- Magali-Wen St-Germain
- Département de Biochimie, de Microbiologie et de Bio-Informatique, Université Laval, Quebec City, QC G1V 0A6, Canada
- Pierre Amato
- Institut de Chimie de Clermont-Ferrand, SIGMA Clermont, CNRS, Université Clermont-Auvergne, 63178 Clermont-Ferrand, France
- Thierry Badard
- Centre de Recherche en Données et Intelligence Géospatiales (CRDIG), Quebec City, QC G1V 0A6, Canada
- Michel G. Bergeron
- Centre de Recherche en Infectiologie, Centre de Recherche du CHU de Québec-Université Laval, Axe Maladies Infectieuses et Immunitaires, Quebec City, QC G1V 4G2, Canada
- Maurice Boissinot
- Centre de Recherche en Infectiologie, Centre de Recherche du CHU de Québec-Université Laval, Axe Maladies Infectieuses et Immunitaires, Quebec City, QC G1V 4G2, Canada
- Steve J. Charette
- Département de Biochimie, de Microbiologie et de Bio-Informatique, Université Laval, Quebec City, QC G1V 0A6, Canada
- Brenda L. Coleman
- Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada
- Jacques Corbeil
- Département de Médecine Moléculaire, Université Laval, Quebec City, QC G1V 0A6, Canada
- Alexander I. Culley
- Département de Biochimie, de Microbiologie et de Bio-Informatique, Université Laval, Quebec City, QC G1V 0A6, Canada
- Marie-Lou Gaucher
- Research Chair in Meat Safety, Département de Pathologie et Microbiologie, Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, Canada
- Matthieu Girard
- Agrivitia Canada, Saskatoon, SK S7N 2Z4, Canada
- Stéphane Godbout
- Institut de Recherche et de Développement en Agroenvironnement (IRDA), Quebec City, QC G1P 3W8, Canada
- Shelley P. Kirychuk
- Department of Medicine, University of Saskatchewan, Saskatoon, SK S7N 0X8, Canada
- André Marette
- Centre de Recherche de L’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec City, QC G1V 4G5, Canada
- Allison McGeer
- Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada
- Patrick T. O’Shaughnessy
- Department of Occupational and Environmental Health, The University of Iowa, Iowa City, IA 52246, USA
- E. Jane Parmley
- Canadian Wildlife Health Cooperative, University of Guelph, Guelph, ON N1G 2W1, Canada
- Serge Simard
- Centre de Recherche de L’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec City, QC G1V 4G5, Canada
- Richard J. Reid-Smith
- Department of Population Medicine, University of Guelph, Guelph, ON N1G 2W1, Canada
- Edward Topp
- Agriculture and Agri-Food Canada, London Research and Development Centre, London, ON N5V 4T3, Canada
- Luc Trudel
- Département de Biochimie, de Microbiologie et de Bio-Informatique, Université Laval, Quebec City, QC G1V 0A6, Canada
- Maosheng Yao
- State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China
- Patrick Brassard
- Département des Sols et de Génie Agroalimentaire, Université Laval, Quebec City, QC G1V 0A6, Canada
- Anne-Marie Delort
- Institut de Chimie de Clermont-Ferrand, SIGMA Clermont, CNRS, Université Clermont-Auvergne, 63178 Clermont-Ferrand, France
- Araceli D. Larios
- Institut de Recherche et de Développement en Agroenvironnement (IRDA), Quebec City, QC G1P 3W8, Canada
- Valérie Létourneau
- Centre de Recherche de L’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec City, QC G1V 4G5, Canada
- Valérie E. Paquet
- Département de Biochimie, de Microbiologie et de Bio-Informatique, Université Laval, Quebec City, QC G1V 0A6, Canada
- Marie-Hélène Pedneau
- Centre de Recherche de L’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec City, QC G1V 4G5, Canada
- Émilie Pic
- Centre de Recherche en Infectiologie, Centre de Recherche du CHU de Québec-Université Laval, Axe Maladies Infectieuses et Immunitaires, Quebec City, QC G1V 4G2, Canada
- Brooke Thompson
- Department of Medicine, University of Saskatchewan, Saskatoon, SK S7N 0X8, Canada
- Marc Veillette
- Centre de Recherche de L’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec City, QC G1V 4G5, Canada
- Mary Thaler
- Département de Biochimie, de Microbiologie et de Bio-Informatique, Université Laval, Quebec City, QC G1V 0A6, Canada
- Ilaria Scapino
- Département de Médecine Moléculaire, Université Laval, Quebec City, QC G1V 0A6, Canada
- Maria Lebeuf
- Centre de Recherche de L’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec City, QC G1V 4G5, Canada
- Mahsa Baghdadi
- Département de Biochimie, de Microbiologie et de Bio-Informatique, Université Laval, Quebec City, QC G1V 0A6, Canada
- Alejandra Castillo Toro
- Department of Medicine, University of Saskatchewan, Saskatoon, SK S7N 0X8, Canada
- Amélia Bélanger Cayouette
- Département de Biochimie, de Microbiologie et de Bio-Informatique, Université Laval, Quebec City, QC G1V 0A6, Canada
- Marie-Julie Dubois
- Centre de Recherche de L’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec City, QC G1V 4G5, Canada
- Alicia F. Durocher
- Département de Biochimie, de Microbiologie et de Bio-Informatique, Université Laval, Quebec City, QC G1V 0A6, Canada
- Sarah B. Girard
- Département de Biochimie, de Microbiologie et de Bio-Informatique, Université Laval, Quebec City, QC G1V 0A6, Canada
- Andrea Katherín Carranza Diaz
- Institut de Recherche et de Développement en Agroenvironnement (IRDA), Quebec City, QC G1P 3W8, Canada
- Asmaâ Khalloufi
- Département de Biochimie, de Microbiologie et de Bio-Informatique, Université Laval, Quebec City, QC G1V 0A6, Canada
- Samantha Leclerc
- Département de Biochimie, de Microbiologie et de Bio-Informatique, Université Laval, Quebec City, QC G1V 0A6, Canada
- Joanie Lemieux
- Département de Biochimie, de Microbiologie et de Bio-Informatique, Université Laval, Quebec City, QC G1V 0A6, Canada
- Manuel Pérez Maldonado
- Department of Population Medicine, University of Guelph, Guelph, ON N1G 2W1, Canada
- Geneviève Pilon
- Centre de Recherche de L’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec City, QC G1V 4G5, Canada
- Colleen P. Murphy
- Centre for Foodborne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Guelph, ON N1G 3W4, Canada
- Charly A. Notling
- Department of Medicine, University of Saskatchewan, Saskatoon, SK S7N 0X8, Canada
- Daniel Ofori-Darko
- Centre for Foodborne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Guelph, ON N1G 3W4, Canada
- Juliette Provencher
- Département de Biochimie, de Microbiologie et de Bio-Informatique, Université Laval, Quebec City, QC G1V 0A6, Canada
- Annabelle Richer-Fortin
- Département de Biochimie, de Microbiologie et de Bio-Informatique, Université Laval, Quebec City, QC G1V 0A6, Canada
- Nathalie Turgeon
- Centre de Recherche de L’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec City, QC G1V 4G5, Canada
- Caroline Duchaine
- Département de Biochimie, de Microbiologie et de Bio-Informatique, Université Laval, Quebec City, QC G1V 0A6, Canada
- DOI
- https://doi.org/10.3390/antibiotics11070974
- Journal volume & issue
-
Vol. 11,
no. 7
p. 974
Abstract
Antimicrobial resistance (AMR) is continuing to grow across the world. Though often thought of as a mostly public health issue, AMR is also a major agricultural and environmental problem. As such, many researchers refer to it as the preeminent One Health issue. Aerial transport of antimicrobial-resistant bacteria via bioaerosols is still poorly understood. Recent work has highlighted the presence of antibiotic resistance genes in bioaerosols. Emissions of AMR bacteria and genes have been detected from various sources, including wastewater treatment plants, hospitals, and agricultural practices; however, their impacts on the broader environment are poorly understood. Contextualizing the roles of bioaerosols in the dissemination of AMR necessitates a multidisciplinary approach. Environmental factors, industrial and medical practices, as well as ecological principles influence the aerial dissemination of resistant bacteria. This article introduces an ongoing project assessing the presence and fate of AMR in bioaerosols across Canada. Its various sub-studies include the assessment of the emissions of antibiotic resistance genes from many agricultural practices, their long-distance transport, new integrative methods of assessment, and the creation of dissemination models over short and long distances. Results from sub-studies are beginning to be published. Consequently, this paper explains the background behind the development of the various sub-studies and highlight their shared aspects.
Keywords
- antibiotic resistance genes
- large-scale monitoring
- one Health
- culturomics
- DNA sequencing
- quantitative PCR
