口腔疾病防治 (Jun 2017)
Serum levels of α2 ⁃ macroglobulin in patients with nasopharyngeal carcinoma radiotherapy and its clinical significance
Abstract
Objective To investigate the changes of α2⁃macroglobulin in different stages of radiotherapy in patients with nasopharyngeal carcinoma, and to explore its feasibility as a marker of serum markers reflecting radiotherapy injury. Methods We collected the blood samples of 23 cases of newly diagnosed patients with nasopharyngeal carcinoma be⁃ fore the simple radiotherapy, the 10, 20, 30 and 33 times after simple radiotherapy, detected the α2⁃ macroglobulin lev⁃ els. The difference among the five stages was analysed by paired t⁃test using SPSS17.0 software package. Results The serum level of α2⁃ macroglobulin elevated with the increase of number of radiotherapy. After 10 times radiotherapy, the serum α2⁃MG concentration in patients with nasopharyngeal carcinoma was significantly higher than that before radio⁃ therapy (12.04 ± 5.72 vs. 10.81 ± 5.38 U/L), the difference was statistically significant (t＝4.818, P < 0.05). After 20 times radiotherapy, the serum α2⁃MG concentration in patients with nasopharyngeal carcinoma was significantly higher than that before radiotherapy (12.26 ± 5.77 vs. 10.81 ± 5.38 U/L), and the difference was statistically significant (t＝ 5.237, P < 0.001). After 30 times radiotherapy, the serum α2⁃MG concentration in patients with nasopharyngeal carci⁃ noma was significantly higher than that before radiotherapy (12.91 ± 5.55 vs. 10.81 ± 5.38 U/L), the difference was sta⁃ tistically significant (t＝6.076, P < 0.05). At the end of radiotherapy, the serum α2⁃MG concentration in nasopharyn⁃ geal carcinoma patients was significantly (13.43 ± 6.05 vs. 10.81 ± 5.38 U/L) higher than that before radiotherapy (t＝ 5.189, P < 0.05). Conclusion The serum level of α2⁃ macroglobulin changes with the radiotherapy, so it can be a se⁃ rum marker reflecting the damage of maxilla induced by ionizing radiation.
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