Медицинская иммунология (Jul 2014)

GENETIC POLYMORPHISMS OF CD14, TNFα AND FCGR2A IN THE PATIENTS WITH INFLUENZA A H1N1 IN TRANSBAIKALIA REGION

  • V. V. Petrov,
  • N. N. Strambovskaya,
  • A. V. Govorin,
  • Yu. A. Vitkovsky

DOI
https://doi.org/10.15789/1563-0625-2011-1-83-86
Journal volume & issue
Vol. 13, no. 1
pp. 83 – 86

Abstract

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Abstract. Relative frequencies of CD14 C-159T, TNFα G-308A and FCGR2A His166Arg genetic polymorphisms were studied in the patients with pandemic influenza A H1N1 in Transbaikalia Region. We have revealed that prevalences of allelic TNFα G-308A and CD14 C-159T variants were identical among the patients and in control group. With CD14 C-159T polymorphism, a C allele proved to be associated with severe and complicated clinical course of disease. The [CD14 (159СС); FCGR2A (166Arg/Arg)] haplotype regictered in two cases, was associated with fulminant course and fatal outcomes of the disease. (Med. Immunol., 2011, vol. 13, N 1, pp 83-86)

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