Nature Communications (Jul 2022)
TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway
- Moïra Rossitto,
- Stephanie Déjardin,
- Chris M. Rands,
- Stephanie Le Gras,
- Roberta Migale,
- Mahmoud-Reza Rafiee,
- Yasmine Neirijnck,
- Alain Pruvost,
- Anvi Laetitia Nguyen,
- Guillaume Bossis,
- Florence Cammas,
- Lionel Le Gallic,
- Dagmar Wilhelm,
- Robin Lovell-Badge,
- Brigitte Boizet-Bonhoure,
- Serge Nef,
- Francis Poulat
Affiliations
- Moïra Rossitto
- Institute of Human Genetics, CNRS UMR9002 University of Montpellier
- Stephanie Déjardin
- Institute of Human Genetics, CNRS UMR9002 University of Montpellier
- Chris M. Rands
- Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva CMU, lab E09.2750.B 1
- Stephanie Le Gras
- GenomEast platform, IGBMC, 1, rue Laurent Fries
- Roberta Migale
- The Francis Crick Institute
- Mahmoud-Reza Rafiee
- The Francis Crick Institute
- Yasmine Neirijnck
- Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva CMU, lab E09.2750.B 1
- Alain Pruvost
- Université Paris Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SPI
- Anvi Laetitia Nguyen
- Université Paris Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SPI
- Guillaume Bossis
- Institut de Génétique Moléculaire de Montpellier (IGMM), University of Montpellier, CNRS
- Florence Cammas
- Institut de Recherche en Cancérologie de Montpellier, IRCM, INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier
- Lionel Le Gallic
- Institute of Human Genetics, CNRS UMR9002 University of Montpellier
- Dagmar Wilhelm
- Department of Anatomy and Physiology, University of Melbourne
- Robin Lovell-Badge
- The Francis Crick Institute
- Brigitte Boizet-Bonhoure
- Institute of Human Genetics, CNRS UMR9002 University of Montpellier
- Serge Nef
- Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva CMU, lab E09.2750.B 1
- Francis Poulat
- Institute of Human Genetics, CNRS UMR9002 University of Montpellier
- DOI
- https://doi.org/10.1038/s41467-022-32061-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 19
Abstract
Gonadal fate in mammals is determined during embryogenesis and is actively maintained in adulthood. This study shows that E3-SUMO ligase activity of TRIM28 is required for ovarian identity maintenance and testicular-specific gene repression in mouse adult ovary; in its absence, ovarian granulosa cells transdifferentiate to Sertoli cells.
