Nature Communications (Jul 2022)

TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway

  • Moïra Rossitto,
  • Stephanie Déjardin,
  • Chris M. Rands,
  • Stephanie Le Gras,
  • Roberta Migale,
  • Mahmoud-Reza Rafiee,
  • Yasmine Neirijnck,
  • Alain Pruvost,
  • Anvi Laetitia Nguyen,
  • Guillaume Bossis,
  • Florence Cammas,
  • Lionel Le Gallic,
  • Dagmar Wilhelm,
  • Robin Lovell-Badge,
  • Brigitte Boizet-Bonhoure,
  • Serge Nef,
  • Francis Poulat

DOI
https://doi.org/10.1038/s41467-022-32061-1
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 19

Abstract

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Gonadal fate in mammals is determined during embryogenesis and is actively maintained in adulthood. This study shows that E3-SUMO ligase activity of TRIM28 is required for ovarian identity maintenance and testicular-specific gene repression in mouse adult ovary; in its absence, ovarian granulosa cells transdifferentiate to Sertoli cells.