Frontiers in Cellular and Infection Microbiology (Mar 2023)

Intracellular persister: A stealth agent recalcitrant to antibiotics

  • Nicolas Personnic,
  • Nicolas Personnic,
  • Patricia Doublet,
  • Patricia Doublet,
  • Sophie Jarraud,
  • Sophie Jarraud,
  • Sophie Jarraud

DOI
https://doi.org/10.3389/fcimb.2023.1141868
Journal volume & issue
Vol. 13

Abstract

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The bulk of bacteria transiently evading appropriate antibiotic regimes and recovered from non-resolutive infections are commonly refer to as persisters. In this mini-review, we discuss how antibiotic persisters stem from the interplay between the pathogen and the cellular defenses mechanisms and its underlying heterogeneity.

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