Nature Communications (Feb 2019)

Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation

  • Keiko Yasuda,
  • Yohko Kitagawa,
  • Ryoji Kawakami,
  • Yoshitaka Isaka,
  • Hitomi Watanabe,
  • Gen Kondoh,
  • Terumi Kohwi-Shigematsu,
  • Shimon Sakaguchi,
  • Keiji Hirota

DOI
https://doi.org/10.1038/s41467-019-08404-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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A chromatin remodelling factor Satb1 is essential for T cell lineage development in the thymus. Here the authors show that while Satb1 is dispensable for the differentiation of Th17 cells and their response to gut commensals, it plays a critical role in pathogenic Th17 effector function in EAE by directly activating Bhlhe40 and modulating PD-1.