Nature Communications (Apr 2019)

Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks

  • Geun-Hyoung Ha,
  • Jae-Hoon Ji,
  • Sunyoung Chae,
  • Jihyun Park,
  • Suhyeon Kim,
  • Jin-Kwan Lee,
  • Yonghyeon Kim,
  • Sunwoo Min,
  • Jeong-Min Park,
  • Tae-Hong Kang,
  • Ho Lee,
  • Hyeseong Cho,
  • Chang-Woo Lee

DOI
https://doi.org/10.1038/s41467-019-09641-9
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 18

Abstract

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Occurrence of DNA double-strand break (DSB) repair is important for genome integrity. Here, the authors reveal that Pellino1 is a DSB-responsive ubiquitin ligase required for promoting the accumulation of ATM and MRN complex at DSB sites via NBS1 ubiquitination.