Nature Communications (Apr 2019)

Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans

  • Chao-Cheng Cho,
  • Chia-Yu Chien,
  • Yi-Chih Chiu,
  • Meng-Hsuan Lin,
  • Chun-Hua Hsu

DOI
https://doi.org/10.1038/s41467-019-09153-6
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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Poly-ADP-ribosylation (PARylation) is a well-known regulatory event in eukaryotes but has not yet been observed in bacteria. Here, the authors solve the structure of a bacterial PAR-glycohydrolase and provide evidence for a prokaryotic PARylation machinery involved in the response to genotoxic stress.