Effect of silibinin on GAS6/sAXL and JAK/STAT pathways in human cholangiocarcinoma cell line

Caliskan Zehra Nur; Ozel Yetkin Merve; Baskol Mevlut; Baskol Gulden

doi:10.1515/tjb-2022-0275

Türk Biyokimya Dergisi (Sep 2024)

Effect of silibinin on GAS6/sAXL and JAK/STAT pathways in human cholangiocarcinoma cell line

Caliskan Zehra Nur,
Ozel Yetkin Merve,
Baskol Mevlut,
Baskol Gulden

Affiliations

Caliskan Zehra Nur: Department of Biochemistry, Faculty of Medicine, Erciyes University, Kayseri, Türkiye
Ozel Yetkin Merve: Department of Biochemistry, Faculty of Medicine, Erciyes University, Kayseri, Türkiye
Baskol Mevlut: Department of Gastroenterology, Erciyes University School of Medicine, Kayseri, Türkiye
Baskol Gulden: Department of Biochemistry, Faculty of Medicine, Erciyes University, Kayseri, Türkiye

DOI: https://doi.org/10.1515/tjb-2022-0275
Journal volume & issue: Vol. 49, no. 5
pp. 637 – 646

Abstract

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Cholangiocarcinoma (CCA) is a highly heterogeneous biliary malignant tumor. Studies have demonstrated that JAK/STAT signaling is activated in many types of cancer. In addition, JAK/STAT is activated downstream of AXL, and the AXL receptor is activated by its ligand, GAS6. In this study, we investigated the anticarcinogenic effect of silibinin and its relationship with the GAS6/AXL ve JAK/STAT pathway in the human EGI-1 cell line.

Published in Türk Biyokimya Dergisi

ISSN: 1303-829X (Online)
Publisher: De Gruyter
Country of publisher: Germany
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.degruyter.com/journal/key/tjb/html

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