Influence of apolipoprotein E and its receptors on cere-bral amyloid precursor protein metabolism following

Abstract

【Abstract】Traumatic brain injury (TBI) is the lead-ing cause of mortality and disability among young indi-viduals in our society, and globally the incidence of TBI is rising sharply. Mounting evidence has indicated that apolipoprotein E (apoE: protein; APOE: gene) genotype in-fluences the outcome after TBI. The proposed mechanism by which APOE affects the clinicopathological conse-quences of TBI is multifactorial and includes amyloid deposition, disruption of lipid distribution, dysfunction of mitochondrial energy production, oxidative stress and in-creases intracellular calcium in response to injury. This pa-per reviews the current state of knowledge regarding the influence of apoE and its receptors on cerebral amyloid beta-protein precursor metabolism following TBI. Key words: Apolipoproteins E; Amyloid beta-pro-tein precursor; Brain injuries