Detection of the UV-vis silent biomarker trimethylamine-N-oxide via outer-sphere interactions in a lanthanide metal-organic framework

Hui Min; Zhonghang Chen; Zongsu Han; Kunyu Wang; Jun Xu; Wei Shi; Peng Cheng

doi:10.1038/s42004-022-00690-8

Communications Chemistry (Jun 2022)

Detection of the UV-vis silent biomarker trimethylamine-N-oxide via outer-sphere interactions in a lanthanide metal-organic framework

Hui Min,
Zhonghang Chen,
Zongsu Han,
Kunyu Wang,
Jun Xu,
Wei Shi,
Peng Cheng

Affiliations

Hui Min: Department of Chemistry, Key Laboratory of Advanced Energy Materials Chemistry (MOE) and Renewable Energy Conversion and Storage Center (RECAST), College of Chemistry, Nankai University
Zhonghang Chen: Department of Chemistry, Key Laboratory of Advanced Energy Materials Chemistry (MOE) and Renewable Energy Conversion and Storage Center (RECAST), College of Chemistry, Nankai University
Zongsu Han: Department of Chemistry, Key Laboratory of Advanced Energy Materials Chemistry (MOE) and Renewable Energy Conversion and Storage Center (RECAST), College of Chemistry, Nankai University
Kunyu Wang: Department of Chemistry, Key Laboratory of Advanced Energy Materials Chemistry (MOE) and Renewable Energy Conversion and Storage Center (RECAST), College of Chemistry, Nankai University
Jun Xu: School of Materials Science and Engineering & National Institute for Advanced Materials Center for Rare Earth and Inorganic Functional Materials, Tianjin Key Lab for Rare Earth Materials and Applications, Nankai University
Wei Shi: Department of Chemistry, Key Laboratory of Advanced Energy Materials Chemistry (MOE) and Renewable Energy Conversion and Storage Center (RECAST), College of Chemistry, Nankai University
Peng Cheng: Department of Chemistry, Key Laboratory of Advanced Energy Materials Chemistry (MOE) and Renewable Energy Conversion and Storage Center (RECAST), College of Chemistry, Nankai University

DOI: https://doi.org/10.1038/s42004-022-00690-8
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 8

Abstract

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Detection of trimethylamine N-oxide (TMAO) can allow for early intervention of cardiovascular disease, but is challenging to achieve using conventional materials and instruments owing to it being spectroscopically silent in the UV-visible region. Here, a series of bilanthanide metalorganic frameworks functionalised with a borono group are shown to detect TMAO with high sensitivity and selectivity by exploiting the inverse emission intensity changes of the two lanthanide centres.

Published in Communications Chemistry

ISSN: 2399-3669 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Chemistry
Website: https://www.nature.com/commschem

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