Molecules
(Jun 2024)
PyBox–La(OTf)<sub>3</sub>-Catalyzed Enantioselective Diels–Alder Cycloadditions of 2-Alkenoylpyridines with Cyclopentadiene
Hao Wei,
Yujie Zhang,
Sanlin Jin,
Ying Yu,
Ning Chen,
Jiaxi Xu,
Zhanhui Yang
Affiliations
Hao Wei
Department of Organic Chemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China
Yujie Zhang
Department of Organic Chemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China
Sanlin Jin
Department of Organic Chemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China
Ying Yu
China United Test & Certification Co., Ltd., Beijing 100088, China
Ning Chen
Department of Organic Chemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China
Jiaxi Xu
Department of Organic Chemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China
Zhanhui Yang
Department of Organic Chemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China
DOI
https://doi.org/10.3390/molecules29132978
Journal volume & issue
Vol. 29,
no. 13
Abstract
Read online
The PyBox–La(OTf)3-catalyzed enantioselective Diels–Alder cycloaddition of 2-alk-2-enoylpyridines with cyclopentadiene is realized, producing enantiopure disubstituted norbornenes, which possess four contiguous stereocenters and are biologically relevant structures in up to 92:8 dr and 99:1 er.
Keywords
WeChat QR code
Close
