Acta Biomedica Scientifica (Apr 2014)
FREQUENCY AND METHODS OF CORRECTION OF MAGNESIUM DEFICIENCY IN YOUNG WOMEN OF REPRODUCTIVE AGE AT TAKING COMBINED ORAL CONTRACEPTIVE PILLS
Abstract
Magnesium is one of the important elements, necessary for the most of biochemical reactions, including those in nerve tissue. Magnesium insufficiency takes a leading position in the structure of elemental status pathology. 20-63 % of females of 18-45 years have borderline or moderate magnesium deficiency. Earlier conducted studies showed decreased level of magnesium in blood serum of women using combined oral contraceptive pills (COCP). We examined 137 young females of reproductive age (average age -19,1 ± 1,1 years) and defined the level of magnesium in blood serum and 24-hour urine at the background of taking COCP. Depending on the level of magnesium in blood serum all women were divided into 2 groups. Females who planned to use COCP and had initially normal level of magnesium in blood serum (n = 88) were randomized to form groups of observation and prophylaxis (with the use of magnesium preparations). All women with reduced level of magnesium (n = 49) together with hormonal contraceptive were prescribed magnesium preparation in combination with pyridoxine. The women with preventive use of magnesium-containing preparation had no significant reduction of magnesium level either in blood or in urine. And the women with reduced Mg level who were taking COCP and received magnesium-containing preparation in combination with pyridoxine had increased level of magnesium in blood serum and 24-hour urine. Thus, prescription of magnesium preparations in combination with pyridoxine to young women of reproductive age using combined oral contraceptive pills has been proved reasonable for reducing the risk of magnesium deficiency.
