Bioactive ZnO Coatings Deposited by MAPLE—An Appropriate Strategy to Produce Efficient Anti-Biofilm Surfaces
Alexandra Elena Oprea,
Loredana Mihaela Pandel,
Ana Maria Dumitrescu,
Ecaterina Andronescu,
Valentina Grumezescu,
Mariana Carmen Chifiriuc,
Laurenţiu Mogoantă,
Tudor-Adrian Bălşeanu,
George Dan Mogoşanu,
Gabriel Socol,
Alexandru Mihai Grumezescu,
Florin Iordache,
Horia Maniu,
Mariana Chirea,
Alina Maria Holban
Affiliations
Alexandra Elena Oprea
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest,1-7 Polizu Street, Bucharest 011061, Romania
Loredana Mihaela Pandel
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest,1-7 Polizu Street, Bucharest 011061, Romania
Ana Maria Dumitrescu
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest,1-7 Polizu Street, Bucharest 011061, Romania
Ecaterina Andronescu
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest,1-7 Polizu Street, Bucharest 011061, Romania
Valentina Grumezescu
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest,1-7 Polizu Street, Bucharest 011061, Romania
Mariana Carmen Chifiriuc
Microbiology Immunology Department, Faculty of Biology, University of Bucharest, 1-3 Portocalelor Lane, Sector 5, Bucharest 77206, Romania
Laurenţiu Mogoantă
Research Center for Microscopic Morphology and Immunology, University of Medicine and Pharmacy of Craiova, Petru Rares Street, No. 2, Craiova 200349, Romania
Tudor-Adrian Bălşeanu
Research Center for Clinical and Experimental Medicine, University of Medicine and Pharmacy of Craiova, Petru Rares Street, No. 2, Craiova 200349, Romania
George Dan Mogoşanu
Department of Pharmacognosy & Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, Petru Rares Street, No. 2, Craiova 200349, Romania
Gabriel Socol
Lasers Department, National Institute for Lasers, Plasma & Materials, P. O. Box MG-36, Magurele 769231, Romania
Alexandru Mihai Grumezescu
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest,1-7 Polizu Street, Bucharest 011061, Romania
Florin Iordache
Flow Cytometry and Cell Therapy Laboratory, Institute of Cellular Biology and Pathology “NicolaeSimionescu” (ICBP), Bucharest 050568, Romania
Horia Maniu
Flow Cytometry and Cell Therapy Laboratory, Institute of Cellular Biology and Pathology “NicolaeSimionescu” (ICBP), Bucharest 050568, Romania
Mariana Chirea
Department of Electrical & Electronics Engineering, IDEALAB, Koç University, Rumeli Feneri Yolu, Sariyer, Istanbul 34450, Turkey
Alina Maria Holban
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest,1-7 Polizu Street, Bucharest 011061, Romania
Deposition of bioactive coatings composed of zinc oxide, cyclodextrin and cefepime (ZnO/CD/Cfp) was performed by the Matrix Assisted Pulsed Laser Evaporation (MAPLE) technique. The obtained nanostructures were characterized by X-ray diffraction, IR microscopy and scanning electron microscopy. The efficient release of cefepime was correlated with an increased anti-biofilm activity of ZnO/CD/Cfp composites. In vitro and in vivo tests have revealed a good biocompatibility of ZnO/CD/Cfp coatings, which recommend them as competitive candidates for the development of antimicrobial surfaces with biomedical applications. The release of the fourth generation cephalosporin Cfp in a biologically active form from the ZnO matrix could help preventing the bacterial adhesion and the subsequent colonization and biofilm development on various surfaces, and thus decreasing the risk of biofilm-related infections.
