Development of chiral metal amides as highly reactive catalysts for asymmetric [3 + 2] cycloadditions

Abstract

Highly efficient catalytic asymmetric [3 + 2] cycloadditions using a chiral copper amide are reported. Compared with the chiral CuOTf/Et3N system, the CuHMDS system showed higher reactivity, and the desired reactions proceeded in high yields and high selectivities with catalyst loadings as low as 0.01 mol %.

Keywords

• [3 + 2] cycloaddition
• asymmetric reaction
• catalytic reaction
• low catalyst loading
• metal amide