Polymorphism of the proinflammatory and anti–inflammatory cytokines genes in patients with an acute pancreatitis in the Northern–Eastern region of Ukraine

Abstract

Objective.To determine the influence of the genes polymorphism of proinflammatory – interleukin–8 A–251T (rs 4073) and antiinflammatory – interleukin–10 C–592A (rs 1800872) cytokines on course of an acute pancreatitis. Materials and methods. The genes polymorphism of proinflammatory – interleukin–8 A–251T (rs 4073) and antiinflammatory – interleukin–10 C–592A (rs 1800872) cytokines were studied in 83 patients with an acute pancreatitis, using the method of polymerase chain reaction (PCR). The control group have consisted of 60 healthy persons without an acute pancreatitis in anamnesis. Results. The rate of the genes polymorphism of interleukin–8 A–251T (rs 4073) and interleukin–10 C–592A (rs 1800872) was determined in oedematious and destructive forms of an acute pancreatitis, as well as in patients operated on. Conclusion. The acute pancreatitis transition into necrotic form was not connected with the kind of the genes polymorphism of proinflammatory – interleukin–8 A–251T (rs 4073) and antiinflammatory – interleukin–10 C–592A (rs 1800872) cytokines. Operative interventions for an acute pancreatitis complications were performed statistically significantlymore frequently in carriers of the T/T gene genotype of interleukin–8 A–251T (rs 4073). The favorable, noncomplicated course of an acute pancreatitis was associated with polymorphism of the A/T gene interleukin–8 A–251T (rs 4073) and, possibly, – with polymorphism of the A/T gene interleukin–10 C–592A (rs 1800872).

Keywords

• acute pancreatitis
• the genes polymorphism of proinflammatory and antiinflammatory cytokines
• complications
• operative treatment