Emerging Infectious Diseases (Feb 2024)

Residual Immunity from Smallpox Vaccination and Possible Protection from Mpox, China

  • Yu Huang,
  • Li Guo,
  • Yanan Li,
  • Lili Ren,
  • Jiqin Nie,
  • Fengwen Xu,
  • Tingxuan Huang,
  • Jingchuan Zhong,
  • Zhangling Fan,
  • Yin Zhang,
  • Yu Xie,
  • Qiao Zhang,
  • Shan Mei,
  • Yan Xiao,
  • Xinming Wang,
  • Liuhui Xu,
  • Fei Guo,
  • Jianwei Wang

DOI
https://doi.org/10.3201/eid3002.230542
Journal volume & issue
Vol. 30, no. 2
pp. 321 – 324

Abstract

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Among persons born in China before 1980 and tested for vaccinia virus Tiantan strain (VVT), 28.7% (137/478) had neutralizing antibodies, 71.4% (25/35) had memory B-cell responses, and 65.7% (23/35) had memory T-cell responses to VVT. Because of cross-immunity between the viruses, these findings can help guide mpox vaccination strategies in China.

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