Thickness of macular area and peripapillary retinal nerve fiber layer in monocular anisometropic amblyopia measured by optical coherence tomography: a Meta-analysis

Yang-Yang Wu; Hong Luo; Jiao Li

doi:10.3980/j.issn.1672-5123.2020.9.19

Guoji Yanke Zazhi (Sep 2020)

Thickness of macular area and peripapillary retinal nerve fiber layer in monocular anisometropic amblyopia measured by optical coherence tomography: a Meta-analysis

Yang-Yang Wu,
Hong Luo,
Jiao Li

Affiliations

Yang-Yang Wu: Department of Ophthalmology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610091, Sichuan Province, China
Hong Luo: Department of Ophthalmology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610091, Sichuan Province, China
Jiao Li: Department of Ophthalmology, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610091, Sichuan Province, China

DOI: https://doi.org/10.3980/j.issn.1672-5123.2020.9.19
Journal volume & issue: Vol. 20, no. 9
pp. 1560 – 1566

Abstract

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AIM: To evaluate the application of optical coherence tomography(OCT)in evaluation of the differences in macular area and peripheral nerve fiber layer thickness(RNFL)of the binocular anisometropic amblyopia of adolescents and children with monocular anisometropic amblyopia, so as to provide a basis for exploring the pathogenesis of amblyopia and guiding the diagnosis and treatment of amblyopia.METHODS: Retrieved Chinese and English databases such as Weipu, WanFang, PubMed, EMBASE etc, and carried out relevant clinical research on the use of OCT to examine macular area and RNFL of adolescents and children with monocular anisometropic amblyopia from 1995-01-01/2019-12-08 screening, evaluation and data extraction, including the thickness of central fovea, central area of macular fovea with diameter 1mm, the inner ring area with 1-3mm, the thickness of the outer ring area with 3-6mm, and the RNFL of monocular anisometropia amblyopia patients into studies, then do Meta-analysis with the RevMan 5.3 software.RESULTS: Results of the time-domain OCT(TD-OCT)study showed that the thickness of macular fovea in the amblyopic eyes and the thickness of the central area of the macular fovea with diameter 1mm were greater than those of the contralateral non-amblyopic eyes(PP>0.05). Results of the study using frequency domain OCT(SD-OCT)showed that the thickness of macular fovea and the thickness of each zone in amblyopic eyes were greater than those of the contralateral non-amblyopic eyes, except for the central area of the macular fovea with diameter 1mm and the outer ring area below 3-6mm. In addition, the rest of the comparisons were different(PPCONCLUSION: Thickness of the macular area and RNFL of the amblyopic eye of monocular anisometropic amblyopia is higher than that of the contralateral non-amblyopic eye, and amblyopia mainly causes the thickness of the macular fovea to increase within 1mm diameter.

Published in Guoji Yanke Zazhi

ISSN: 1672-5123 (Print)
Publisher: Press of International Journal of Ophthalmology (IJO PRESS)
Country of publisher: China
LCC subjects: Medicine: Ophthalmology
Website: http://ies.ijo.cn/

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