PLoS ONE (Jan 2020)

Impact of diabetes, obesity and hypertension on preterm birth: Population-based study.

  • Howard Berger,
  • Nir Melamed,
  • Beth Murray Davis,
  • Haroon Hasan,
  • Karizma Mawjee,
  • Jon Barrett,
  • Sarah D McDonald,
  • Michael Geary,
  • Joel G Ray

DOI
https://doi.org/10.1371/journal.pone.0228743
Journal volume & issue
Vol. 15, no. 3
p. e0228743

Abstract

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ObjectiveTo determine the impact of pre-pregnancy diabetes mellitus (D), obesity (O) and chronic hypertension (H) on preterm birth (PTB).MethodsRetrospective population-based cohort study in Ontario, Canada between 2012-2016. Women who had a singleton livebirth or stillbirth at > 20 weeks gestation were included in the cohort. Exposures of interest were D, O and H, individually, and in various combinations. The primary outcome was PTB at 241/7 to 366/7 weeks. PTB was further analyzed by spontaneous or provider-initiated, early (Results506,483 women were eligible for analysis. 30,139 pregnancies (6.0%) were complicated by PTB ConclusionCombinations of DOH significantly magnify the risk of PTB, especially provider initiated PTB, and PTB with altered fetal growth or preeclampsia.