Nature Communications (Sep 2022)

Estimating individual treatment effect on disability progression in multiple sclerosis using deep learning

  • Jean-Pierre R. Falet,
  • Joshua Durso-Finley,
  • Brennan Nichyporuk,
  • Julien Schroeter,
  • Francesca Bovis,
  • Maria-Pia Sormani,
  • Doina Precup,
  • Tal Arbel,
  • Douglas Lorne Arnold

DOI
https://doi.org/10.1038/s41467-022-33269-x
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

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There are limited predictive biomarkers for drug treatment responses in individuals with multiple sclerosis. Here using existing clinical trials data, the authors propose a deep-learning predictive enrichment strategy to identify which participants are most likely to respond to a treatment.