APACHE-II score for anti-tuberculosis tolerance in critically ill patients: a retrospective study

Abstract

Abstract Background To investigate the status of anti-tuberculosis treatment in critically ill patients, and to explore the value of APACHE-II score in guiding anti-tuberculosis treatment. Methods This analysis included critically ill patients with tuberculosis. The utility of APACHE-II score for predicting drug withdrawal was evaluated using receiver operating characteristic (ROC) curve analysis. Results Among 320 patients enrolled (58 ± 22 years; 256 males), 147 (45.9%) had drugs withdrawn. The drug withdrawal group had higher APACHE-II score (median [interquartile range]: 21 [3–52] vs. 17 [4–42] points), higher CD4%, lower hemoglobin level, higher rates of chronic obstructive pulmonary disease (COPD) and chronic renal failure, and lower rate of extrapulmonary tuberculosis (P 18 (odds ratio [95% confidence interval]: 2.099 [1.321–3.334], P 18 points might predict patient tolerance of anti-tuberculosis treatment.

Keywords

• Tuberculosis
• Critical illness
• APACHE-II
• Drug tolerance