Retraction: Development and optimization of TPGS/P84 mixed polymeric micelles: enhanced stability and anticancer effect of paclitaxel against tumor therapy

Abstract

Dear Editor, In our subsequent study after the receipt of the article, it was found that the P84Ms carrier had certain cytotoxicity. As can be seen from the Figure 1 and Figure 2, compared with the cells in the control group, after incubation with different prepare preparations, the single carrier group Micelles-Blank and Mixed Micelles-Blank could inhibit the growth of the cells. However, the cytotoxicity data in the paper did not set Micelles-Blank and Mixed Micelles-Blank groups, which was also an oversight of our design at that time. Hence it is hard to say whether the therapeutic effect of the preparation is due to the toxicity of the carrier or the therapeutic effect of the drug in this article Therefore, the statement in the article that the carrier is safe and effective may be wrong. So the article needs to be withdrawn, and we will further modify the carrier in the future to reduce its toxicity.

Keywords

• tpgs
• micelle
• paclitaxel
• tumor therapy
• p84