GABAergic interneurons form transient layer-specific circuits in early postnatal neocortex

Paul G. Anastasiades; Andre Marques-Smith; Daniel Lyngholm; Tom Lickiss; Sayda Raffiq; Dennis Kätzel; Gero Miesenböck; Simon J. B. Butt

doi:10.1038/ncomms10584

Nature Communications (Feb 2016)

GABAergic interneurons form transient layer-specific circuits in early postnatal neocortex

Paul G. Anastasiades,
Andre Marques-Smith,
Daniel Lyngholm,
Tom Lickiss,
Sayda Raffiq,
Dennis Kätzel,
Gero Miesenböck,
Simon J. B. Butt

Affiliations

Paul G. Anastasiades: Department of Physiology, Anatomy and Genetics, University of Oxford
Andre Marques-Smith: Department of Physiology, Anatomy and Genetics, University of Oxford
Daniel Lyngholm: Department of Physiology, Anatomy and Genetics, University of Oxford
Tom Lickiss: Department of Physiology, Anatomy and Genetics, University of Oxford
Sayda Raffiq: Centre for Neuroscience, Imperial College Faculty of Medicine, Hammersmith Hospital, Imperial College London
Dennis Kätzel: Department of Physiology, Anatomy and Genetics, University of Oxford
Gero Miesenböck: Department of Physiology, Anatomy and Genetics, University of Oxford
Simon J. B. Butt: Department of Physiology, Anatomy and Genetics, University of Oxford

DOI: https://doi.org/10.1038/ncomms10584
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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GABAergic interneurons are key components of cortical circuits, yet their early connectivity is unknown. Here the authors show that during early postnatal development,Nkx2-1-derived interneurons engage in layer-specific and dynamic circuits, which are distinct from those in the mature neocortex.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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