Ca2+-activated Cl− channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration

Anamika Dayal; Shu Fun J. Ng; Manfred Grabner

doi:10.1038/s41467-018-07918-z

Nature Communications (Jan 2019)

Ca2+-activated Cl− channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration

Anamika Dayal,
Shu Fun J. Ng,
Manfred Grabner

Affiliations

Anamika Dayal: Department of Medical Genetics, Molecular and Clinical Pharmacology, Division of Biochemical Pharmacology, Medical University of Innsbruck
Shu Fun J. Ng: Department of Medical Genetics, Molecular and Clinical Pharmacology, Division of Biochemical Pharmacology, Medical University of Innsbruck
Manfred Grabner: Department of Medical Genetics, Molecular and Clinical Pharmacology, Division of Biochemical Pharmacology, Medical University of Innsbruck

DOI: https://doi.org/10.1038/s41467-018-07918-z
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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The Ca2+-activated Cl- channel TMEM16A/Anoctamin 1 (ANO1) mediates secretion and intestinal motility in gastrointestinal epithelia and smooth muscle cells. Here, the authors show a role for ANO1 in zebrafish skeletal muscle which is activated by SR Ca2+ release during excitation-contraction coupling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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