Anterior segment measurements and determinants of angle width with short, medium, and long axial lengths in a rural Chinese population

Abstract

Purpose: To report the anterior segment measurements and investigate the determinants of angle width with short, medium, and long axial length (AL) in a rural Chinese population. Design: Observational, population-based, cross-sectional study. Methods: Subjects aged ≥35 years who underwent complete ocular examinations during the follow-up of the Handan Eye Study were included. Ocular data of the right eye were analyzed. Anterior segment parameters were obtained and stratified by age and sex. AL was categorized into short (23.5 mm) subgroups. Linear regression analyses were performed to identify the parameters associated with angle width (angle opening distance at 500 μm from the scleral spur (SS) [AOD500]). Results: The final analysis included 4435 subjects (58.0 [49.0, 64.0] years old, 44.1% males). Smaller AOD500 was significantly associated with female sex (P = 0.032), larger iris thickness at 750 μm from the SS (IT750) (P < 0.001), larger lens vault (LV) (P < 0.001), and smaller anterior chamber volume (ACV) (P < 0.001) in the short AL subgroup; larger sphere equivalent (SE), IT750, iris curvature (IC), and LV and smaller ACV (all P < 0.001) in the medium AL subgroup; and larger SE, IT750, IA, IC, and LV and smaller ACV (all P < 0.001) in the long AL subgroup. Conclusions: Our study provides the anterior segment parameters of a large rural Chinese population. IT750, ACV, and LV were found to be the most important factors associated with angle width.

Keywords

• Rural population
• Anterior segment
• Angle width
• Chinese
• Axial length