Nature Communications (Apr 2018)
Inhibition of the mevalonate pathway enhances cancer cell oncolysis mediated by M1 virus
- Jiankai Liang,
- Li Guo,
- Kai Li,
- Xiao Xiao,
- Wenbo Zhu,
- Xiaoke Zheng,
- Jun Hu,
- Haipeng Zhang,
- Jing Cai,
- Yaya Yu,
- Yaqian Tan,
- Chuntao Li,
- Xincheng Liu,
- Cheng Hu,
- Ying Liu,
- Pengxin Qiu,
- Xingwen Su,
- Songmin He,
- Yuan Lin,
- Guangmei Yan
Affiliations
- Jiankai Liang
- Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University
- Li Guo
- Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University
- Kai Li
- Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital of Sun Yat-sen University
- Xiao Xiao
- Department of Pharmacy, The Third Affiliated Hospital of Sun Yat-sen University
- Wenbo Zhu
- Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University
- Xiaoke Zheng
- Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University
- Jun Hu
- Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University
- Haipeng Zhang
- Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University
- Jing Cai
- Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University
- Yaya Yu
- Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University
- Yaqian Tan
- Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University
- Chuntao Li
- Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University
- Xincheng Liu
- Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University
- Cheng Hu
- Department of Urology, The Third Affiliated Hospital of Sun Yat-sen University
- Ying Liu
- Department of Infectious Disease, The Third Affiliated Hospital of Sun Yat-sen University
- Pengxin Qiu
- Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University
- Xingwen Su
- Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University
- Songmin He
- Appel Alzheimer’s Disease Research Institute, Brain and Mind Research Institute, Weill Cornell Medical College
- Yuan Lin
- Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University
- Guangmei Yan
- Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University
- DOI
- https://doi.org/10.1038/s41467-018-03913-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Oncolytic viruses selectively kill tumour cells and induce anti-tumour immunity. Here, the AUs demonstrate the anti-viral effect of the mevalonate pathway on oncolytic virus M1 in refractory cancer cells and provide evidence for a combination strategy of targeting the mevalonate pathway for potentiating oncolytic virus therapy.
