Influence of Surface Charge on Biological Behaviour of Gold Nanoparticles in Human SH-SY5Y Neuronal Cells

Vanessa Valdiglesias; Mónica Paz; Assia Touzani; Sandra Baúlde; Jesús Mosquera; Alejandro Criado; Eduardo Pásaro; Josefina Méndez; Blanca Laffon; Natalia Fernández-Bertólez

doi:10.3390/IOCN2023-14516

Materials Proceedings (May 2023)

Influence of Surface Charge on Biological Behaviour of Gold Nanoparticles in Human SH-SY5Y Neuronal Cells

Vanessa Valdiglesias,
Mónica Paz,
Assia Touzani,
Sandra Baúlde,
Jesús Mosquera,
Alejandro Criado,
Eduardo Pásaro,
Josefina Méndez,
Blanca Laffon,
Natalia Fernández-Bertólez

Affiliations

Vanessa Valdiglesias: Universidade da Coruña, Grupo NanoToxGen, Centro Interdisciplinar de Química e Bioloxía—CICA, Departamento de Biología, Facultad de Ciencias, Campus A Zapateira s/n, 15071 A Coruña, Spain
Mónica Paz: Universidade da Coruña, Grupo Nanoself, Centro Interdisciplinar de Química e Bioloxía—CICA, Departamento de Química, Facultad de Ciencias, Campus A Zapateira s/n, 15071 A Coruña, Spain
Assia Touzani: Universidade da Coruña, Grupo NanoToxGen, Centro Interdisciplinar de Química e Bioloxía—CICA, Departamento de Biología, Facultad de Ciencias, Campus A Zapateira s/n, 15071 A Coruña, Spain
Sandra Baúlde: Universidade da Coruña, Grupo Nanoself, Centro Interdisciplinar de Química e Bioloxía—CICA, Departamento de Química, Facultad de Ciencias, Campus A Zapateira s/n, 15071 A Coruña, Spain
Jesús Mosquera: Universidade da Coruña, Grupo Nanoself, Centro Interdisciplinar de Química e Bioloxía—CICA, Departamento de Química, Facultad de Ciencias, Campus A Zapateira s/n, 15071 A Coruña, Spain
Alejandro Criado: Universidade da Coruña, Grupo Nanoself, Centro Interdisciplinar de Química e Bioloxía—CICA, Departamento de Química, Facultad de Ciencias, Campus A Zapateira s/n, 15071 A Coruña, Spain
Eduardo Pásaro: Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Xubias de Arriba 84, 15006 A Coruña, Spain
Josefina Méndez: Universidade da Coruña, Grupo NanoToxGen, Centro Interdisciplinar de Química e Bioloxía—CICA, Departamento de Biología, Facultad de Ciencias, Campus A Zapateira s/n, 15071 A Coruña, Spain
Blanca Laffon: Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Xubias de Arriba 84, 15006 A Coruña, Spain
Natalia Fernández-Bertólez: Universidade da Coruña, Grupo NanoToxGen, Centro Interdisciplinar de Química e Bioloxía—CICA, Departamento de Biología, Facultad de Ciencias, Campus A Zapateira s/n, 15071 A Coruña, Spain

DOI: https://doi.org/10.3390/IOCN2023-14516
Journal volume & issue: Vol. 14, no. 1
p. 52

Abstract

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Gold nanoparticles (AuNPs) are one of the most remarkable nanomaterials. Due to their small size, these NPs can cross the blood–brain barrier making them good candidates for the treatment of diseases related to the central nervous system. The main objective of the present work was to evaluate the influence of surface charge on the biological behaviour of AuNPs by assessing the cytotoxic—viability and morphological alterations—and genotoxic—double strand breaks—effects induced in neuronal cells exposed to AuNPs with different charges: cationic, anionic, and neutral. Different toxicological behaviours were obtained depending on the surface charge of the NPs.

Published in Materials Proceedings

ISSN: 2673-4605 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Chemical technology: Chemical engineering
Website: https://www.mdpi.com/journal/materproc

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