Reações intramoleculares como modelos não miméticos de catálise enzimática Intramolecular reactions as non mimetic models of enzyme catalysis

Abstract

This review gives a critical idea on the importance of intramolecular reactions as models for enzymatic catalysis. Intramolecular lactonizations, ester and amide hydrolysis studies result in theories which try to explain the difference between intermolecular, intramolecular and enzyme reactions and rationalize the enhancement promoted by these biological catalyst.

Keywords

• enzymatic catalysis
• intramolecular reactions
• nonmimetic enzyme models