Lecithin-Polysaccharide Self-Assembled Microspheres for Resveratrol Delivery
Lei Wang,
Congting Lai,
Dong Li,
Zisheng Luo,
Lingling Liu,
Yunbin Jiang,
Li Li
Affiliations
Lei Wang
Key Laboratory of Agro-Products Postharvest Handling, Ministry of Agriculture and Rural Affairs, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China
Congting Lai
Key Laboratory of Agro-Products Postharvest Handling, Ministry of Agriculture and Rural Affairs, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China
Dong Li
Key Laboratory of Agro-Products Postharvest Handling, Ministry of Agriculture and Rural Affairs, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China
Zisheng Luo
Key Laboratory of Agro-Products Postharvest Handling, Ministry of Agriculture and Rural Affairs, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China
Lingling Liu
School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China
Yunbin Jiang
Tianjin Gasin-DH Preservation Technologies Co., Ltd., Tianjin 300403, China
Li Li
Key Laboratory of Agro-Products Postharvest Handling, Ministry of Agriculture and Rural Affairs, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China
Poor water solubility and low chemical stability, seriously limit the efficient bioavailability of resveratrol. Here, we propose encapsulating resveratrol in lecithin-polysaccharide self-assembled microspheres (LPSM). An LPSM was designed with a lecithin core, and alginate-carboxymethyl chitosan biolayer shell. The LPSM had a spherical shape with 12.171 ± 0.960 μm of particle size and −30.86 ± 1.37 mV of zeta potential. The introduce of lecithin remarkably increased the encapsulation efficiency of resveratrol to 92.78 ± 0.82%. The LPSM elevated the antioxidant capacity and ultraviolet resistance of resveratrol. Moreover, LPSM inhibited release in a simulated gastric environment, promoted sustained release in simulated intestinal environment, and elevated the bioavailability of resveratrol during in vitro simulated digestion. Results indicate that LPSM is promising as a carrier for resveratrol delivery to enhance stability and bioaccessibility.
