Cellular and molecular signatures of in vivo imaging measures of GABAergic neurotransmission in the human brain

Paulina Barbara Lukow; Daniel Martins; Mattia Veronese; Anthony Christopher Vernon; Philip McGuire; Federico Edoardo Turkheimer; Gemma Modinos

doi:10.1038/s42003-022-03268-1

Communications Biology (Apr 2022)

Cellular and molecular signatures of in vivo imaging measures of GABAergic neurotransmission in the human brain

Paulina Barbara Lukow,
Daniel Martins,
Mattia Veronese,
Anthony Christopher Vernon,
Philip McGuire,
Federico Edoardo Turkheimer,
Gemma Modinos

Affiliations

Paulina Barbara Lukow: Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London
Daniel Martins: Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King’s College London
Mattia Veronese: Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King’s College London
Anthony Christopher Vernon: Department of Basic & Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute
Philip McGuire: Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London
Federico Edoardo Turkheimer: Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King’s College London
Gemma Modinos: Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London

DOI: https://doi.org/10.1038/s42003-022-03268-1
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

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Molecular origin of GABA receptor PET tracer signal is probed by performing correlation studies using regional PET signal and gene expression levels of GABA receptors and inhibitory interneuron markers. The results provide insight in the application and interpretation of these GABA receptor PET tracers in clinical populations.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal