Pathogenesis and therapy of anemia in oncohemathology patients with recombinant erythropoietin agents (review)

Abstract

The article presents a literature review on the mechanisms of anemia in patients with hematologic malignancies and a classification of chronic anemia and methods of its correction. It describes in detail the mechanism of action, indications and side effects of rembinant erythropoietin (rEPO). It gives anemia treatment algorithms with rEPO in patients with chronic blood malignancies. The analysis of rEPO efficacy is shown in anemia treatment in patients with various types of cancer. It presents the recommendations of ASCO/ASH for the use of rEPO in various patients categories.

Keywords

• anemia
• non Hodgkin’s lymphomas
• lymphoproliferative disorders
• multiple myeloma
• chronic myeloid leukemia
• myelodisplastic syndrome
• hemoglobin
• erythropoietin
• darbepoetin
• chemotherapy
• red blood cell transfusion