GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis

Abstract

GPRC5A is a retinoic acid inducible gene that is preferentially expressed in lung tissue. Here the authors report that GPRC5A suppresses the translation of EGFR by interfering with the eIF4F complex assembly, thereby limiting lung tumorigenesis, particularly radiation-induced lung tumorigenesis.