Global Journal of Transfusion Medicine (Jan 2022)

Effect of donor and patient variables on the platelet increment and percent platelet recovery: Experience from tertiary care center in North-Western India

  • Sarita Sharma,
  • Praveen Kumar Joshi,
  • Sunita Bundas,
  • Amit Sharma

DOI
https://doi.org/10.4103/gjtm.gjtm_37_22
Journal volume & issue
Vol. 7, no. 2
pp. 196 – 200

Abstract

Read online

Background and Objectives: Platelet (PLT) deficiency is a common cause of bleeding and PLT transfusions are often indicated for the same. PLT refractoriness is a challenging complication in patients dependent on PLT transfusions. The present study aimed to find out any effect of the donor, recipient, and machine variables on PLT increment (PI) and percent PLT recovery. Patient and Methods: A total of 600 apheresis PLT donors and 600 patients were included in this study; however, the PI and percent platelet recovery (PPR) were analyzed for only 535 patients. The data were collected such as the donor's age, gender, preapheresis hemoglobin (Hb), PLT count, PLT product yield, patient's age, gender, weight, pre- and posttransfusion Hb, and PLT count. PI and PPR were calculated and compared across different groups. Results: Refractoriness was more seen in hematological disorders in comparison to nonhematological disorders (P = 0.00001). However, no significant association of donor and recipient characteristics with PI was seen. Conclusion: PI does not depend on recipient characteristics such as age, gender, pretransfusion PLT count, and Hb.

Keywords