Microbiology Indonesia (Jan 2020)

Polyoxygenated Diterpene Produced by The Indonesian Marine Sponge Callyspongiasp. as an Inhibitor of the Human Pancreatic Cancer Cells

  • VIQQI KURNIANDA,
  • SUCI FARADILLA,
  • SOFYATUDDIN KARINA,
  • SRI AGUSTINA,
  • MARIA ULFAH,
  • CHITRA OCTAVINA,
  • FARAH SYAHLIZA,
  • MUHAMMAD RIZKI RAMADHAN,
  • SYAHRUL PURNAWAN,
  • MUSRI MUSMAN

DOI
https://doi.org/10.5454/mi.13.2.5
Journal volume & issue
Vol. 13, no. 2

Abstract

Read online

The bioactive compound from the Indonesian Marine SpongeCallyspongia sp.isolated based on bioassay-guided separation with several steps of chromatography has been done. There are 4 major compound known as isocopalane diterpene derivatives together with a plausible new compound, isocopalanol, a polyoxygenated isocopalane diterpene. Isocopalanol has molecular weight [M+H]+ 412.576 m/z indicate that the compound has molecular formula C24H44O5 determined by LCMS-ESI. This compound has bioactivity IC50 = 0.1 μg / mL against human pancreatic cancer cell.

Keywords