Radiology Case Reports (Sep 2023)

Vanishing bile duct syndrome-related jaundice as the first presentation of Hodgkin lymphoma

  • Milad Mellat-Ardakani, MD-MPH,
  • Faeze Salahshour,
  • Katayoun Rafsanjani, MD,
  • Foroogh Alborzi Avanaki,
  • Maryam Azizi

Journal volume & issue
Vol. 18, no. 9
pp. 3291 – 3294

Abstract

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Vanishing bile duct syndrome is a rare, acquired disease that has been described in different pathologic conditions‚ including adverse drug reactions, autoimmune diseases, graft vs host disease, and neoplasms. It is a condition characterized by progressive loss of intrahepatic bile ducts leading to ductopenia and cholestasis.Here we report a 27-year-old female who presented with jaundice and cholestatic hepatitis and was finally diagnosed with vanishing Bile duct syndrome secondary to Hodgkin lymphoma.Physicians need to consider a range of differential diagnoses, especially malignancies, in suspected cases of vanishing bile duct syndrome.

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