Diversity in microbiota between Indian and Emiratis ethnicities is associated with benign prostatic hyperplasia

Abstract

Background: Herein, we investigated the correlation between microbiota profile and benign prostatic hyperplasia (BPH) in patients from two different ethnicities, Indian and United Arab Emirates. Materials and Methods: Prostate samples were collected from patients in Al Baraha Hospital in Sharjah, United Arab Emirates. Next, metagenomic analysis of bacterial species was carried out by extracting DNA and 16S rRNA analysis. Results: Our results revealed that the gut bacterial communities of the Indian and Emirati populations were different. Principal coordinates analyses revealed differences in the bacterial community structure. Around 265 bacterial operational taxonomic units (OTUs) were specific to the Indian population vs. 968 bacterial OTUs observed in the Emirati population, whereas 586 bacterial OTUs were common to both groups. When the relative abundance of taxa was analyzed, Proteobacteria, Actinobacteriota, and Firmicutes represented the highest abundance, albeit the relative abundance was different between the two groups. At the genus level, the distribution of the genus Ralstonia was most abundant in the Emirati population followed by Pseudomonas, whereas Acinetobacter was the most abundant in the Indian population followed by Stenotrophomonas. Likewise, differences were observed between other genera in both groups. MetaStats analysis revealed that 21 bacterial species were considerably different between the two groups. Conclusion: Collectively, the data revealed that both groups showed differences in the structure of bacterial community. Further studies are warranted to determine the precise role of specific bacterial species in BPH and the underlying molecular mechanisms. The findings arising from these studies will be important in the rational development of therapeutic interventions.

Keywords

• benign prostatic hyperplasia
• gut microbiome
• metabolites