THE INFLUENCE OF MODERN PLASMA SUBSTITUTES ON THE COURSE OF ABDOMINAL COMPARTMENT SYNDROME IN PATIENTS WITH ABDOMINAL SEPSIS

Abstract

The changes of intra-abdominal pressure (IAP) were followed up in 244 patients with abdominal sepsis after operation. The influence of liquid «resuscitation» with different types of plasma substitutes on the rates of IAP was studied and the dependence of changes IAP from filling of vascular bed was investigated. The impedance technique was used to determine the circulating blood volume and its percentage from proper index was estimated according to the sex, age and constitution. The percentage of interstitial liquid in organism was calculated by analogy. The severity of manifestations of abdominal compartment syndrome (ACS) increases with the assessment of severity of the general condition to APACHE-II scale. The most severe ACS course was while using the crystalloid solutions in the complex of infusion therapy. The inclusion of colloids in the infusion therapy facilitated more full volume filling of vascular bed with the liquid, reduced the capillary leakage, accelerated the process of reduction of ACS. The advantage was shown by using the derivatives of hydroxyethylstarch, which promoted the elimination of deficiency of intravascular liquid in the best way.

Keywords

• абдоминальный сепсис
• абдоминальный компартмент-синдром
• кристаллоиды
• гидроксиэтилкрахмал
• модифицированная желатина
• abdominal sepsis
• compartment syndrome
• crystalloids
• hydroxyethylstarch
• modified gelatin