Arrangement and symmetry of the fungal E3BP-containing core of the pyruvate dehydrogenase complex

B. O. Forsberg; S. Aibara; R. J. Howard; N. Mortezaei; E. Lindahl

doi:10.1038/s41467-020-18401-z

Nature Communications (Sep 2020)

Arrangement and symmetry of the fungal E3BP-containing core of the pyruvate dehydrogenase complex

B. O. Forsberg,
S. Aibara,
R. J. Howard,
N. Mortezaei,
E. Lindahl

Affiliations

B. O. Forsberg: Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University
S. Aibara: Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University
R. J. Howard: Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University
N. Mortezaei: Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University
E. Lindahl: Department of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University

DOI: https://doi.org/10.1038/s41467-020-18401-z
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 10

Abstract

Read online

The pyruvate dehydrogenase complex (PDC) is a multienzyme complex connecting glycolysis to mitochondrial oxidation of pyruvate. Cryo-EM analysis of PDC from Neurospora crassa reveals localization of fungi-specific protein X (PX) and confirms that it functions like the mammalian E3BP, recruiting the E3 component of PDC.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal