Ultrasound-controllable engineered bacteria for cancer immunotherapy

Mohamad H. Abedi; Michael S. Yao; David R. Mittelstein; Avinoam Bar-Zion; Margaret B. Swift; Audrey Lee-Gosselin; Pierina Barturen-Larrea; Marjorie T. Buss; Mikhail G. Shapiro

doi:10.1038/s41467-022-29065-2

Nature Communications (Mar 2022)

Ultrasound-controllable engineered bacteria for cancer immunotherapy

Mohamad H. Abedi,
Michael S. Yao,
David R. Mittelstein,
Avinoam Bar-Zion,
Margaret B. Swift,
Audrey Lee-Gosselin,
Pierina Barturen-Larrea,
Marjorie T. Buss,
Mikhail G. Shapiro

Affiliations

Mohamad H. Abedi: Division of Biology and Biological Engineering, California Institute of Technology
Michael S. Yao: Division of Biology and Biological Engineering, California Institute of Technology
David R. Mittelstein: Division of Engineering and Applied Sciences, California Institute of Technology
Avinoam Bar-Zion: Division of Chemistry and Chemical Engineering, California Institute of Technology
Margaret B. Swift: Division of Chemistry and Chemical Engineering, California Institute of Technology
Audrey Lee-Gosselin: Division of Chemistry and Chemical Engineering, California Institute of Technology
Pierina Barturen-Larrea: Division of Chemistry and Chemical Engineering, California Institute of Technology
Marjorie T. Buss: Division of Chemistry and Chemical Engineering, California Institute of Technology
Mikhail G. Shapiro: Division of Chemistry and Chemical Engineering, California Institute of Technology

DOI: https://doi.org/10.1038/s41467-022-29065-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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Synthetic biology has enabled the design of strategies for bacteria-based cancer immunotherapy. Here the authors report the development of focused ultrasound-activatable therapeutic bacteria engineered to express anti-CTLA-4 and anti-PD-L1 nanobodies for cancer immunotherapy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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