Stability of Concentrated Solution of Vancomycin Hydrochloride in Syringes for Intensive Care Units

Abstract

Vancomycin is increasingly administrated by continuous infusion. But the treatment of patient in intensive care need restricted volume to prevent fluid overload. The aim of the study was to evaluate the physical and chemical stability of solutions of a high concentration of vancomycin hydrochloride in 5 % glucose or 0.9 % NaCl.

Keywords

• vancomycin infusions
• concentrated solutions
• high performance liquid chromatography
• physicochemical stability
• syringe
• intensive care units