Nature Communications (Apr 2016)

Super-complexes of adhesion GPCRs and neural guidance receptors

  • Verity A. Jackson,
  • Shahid Mehmood,
  • Matthieu Chavent,
  • Pietro Roversi,
  • Maria Carrasquero,
  • Daniel del Toro,
  • Goenuel Seyit-Bremer,
  • Fanomezana M. Ranaivoson,
  • Davide Comoletti,
  • Mark S. P. Sansom,
  • Carol V. Robinson,
  • Rüdiger Klein,
  • Elena Seiradake

DOI
https://doi.org/10.1038/ncomms11184
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 13

Abstract

Read online

FLRT proteins are known to interact with Lphns and Unc5s, mediating cell adhesion and repulsion respectively. Here the authors use crystallography, native mass spectrometry, molecular dynamics simulations and cell-based assays to show that these three proteins form large super-complexes with functions distinct from their smaller subcomplexes.