Revista da Sociedade Brasileira de Medicina Tropical ()

Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice

  • Erica de Souza Fernandes,
  • Virgínia Maria de Barros Lorena,
  • Iana Rafaela Fernandes Sales,
  • Mônica Camelo Pessoa de Azevedo Albuquerque,
  • Yara de Miranda Gomes,
  • Vlaudia Maria Assis Costa,
  • Valdênia Maria Oliveira de Souza

DOI
https://doi.org/10.1590/0037-8682-0338-2016
Journal volume & issue
Vol. 51, no. 4
pp. 546 – 549

Abstract

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Abstract INTRODUCTION: We evaluated IL-10, IL-2 and regulatory T cells (Treg), in response to ovalbumin (OA), in offspring from schistosomotic mouse mothers. METHODS: We used animals born (BIM) or suckled (SIM) from infected mothers; and mice born/suckled from infected (BSIM) or non-infected mothers (CONTROL). After OA+adjuvant immunization, spleen cells were cultured, with or without OA, and doubly marked for cytometry. RESULTS: BIM showed fewer CD4+/IL-2+ and more B220+/IL-10+ cells, whereas the SIM group showed increased Treg frequency. BSIM had fewer B220+/IL-10+ and Treg cells. CONCLUSIONS: Separately, gestation or nursing induced immunosuppressive cells in infected mothers, but improved anti-OA immunity when combined.

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