The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA

Sina Wittmann; Max Renner; Beth R. Watts; Oliver Adams; Miles Huseyin; Carlo Baejen; Kamel El Omari; Cornelia Kilchert; Dong-Hyuk Heo; Tea Kecman; Patrick Cramer; Jonathan M. Grimes; Lidia Vasiljeva

doi:10.1038/ncomms14861

Nature Communications (Apr 2017)

The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA

Sina Wittmann,
Max Renner,
Beth R. Watts,
Oliver Adams,
Miles Huseyin,
Carlo Baejen,
Kamel El Omari,
Cornelia Kilchert,
Dong-Hyuk Heo,
Tea Kecman,
Patrick Cramer,
Jonathan M. Grimes,
Lidia Vasiljeva

Affiliations

Sina Wittmann: Department of Biochemistry, University of Oxford
Max Renner: Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford
Beth R. Watts: Department of Biochemistry, University of Oxford
Oliver Adams: Department of Biochemistry, University of Oxford
Miles Huseyin: Department of Biochemistry, University of Oxford
Carlo Baejen: Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry
Kamel El Omari: Diamond Light Source Ltd, Harwell Science & Innovation Campus
Cornelia Kilchert: Department of Biochemistry, University of Oxford
Dong-Hyuk Heo: Department of Biochemistry, University of Oxford
Tea Kecman: Department of Biochemistry, University of Oxford
Patrick Cramer: Department of Molecular Biology, Max Planck Institute for Biophysical Chemistry
Jonathan M. Grimes: Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford
Lidia Vasiljeva: Department of Biochemistry, University of Oxford

DOI: https://doi.org/10.1038/ncomms14861
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

Read online

Termination of RNA polymerase II is a critical step in transcription. Here, the authors provide evidence that the fission yeast CID-RRM protein Seb1 is required for termination of coding and non-coding genes through interaction with both the polymerase and the nascent RNA.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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