Nature Communications (Sep 2020)
ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration
- Gururaj Rao Kidiyoor,
- Qingsen Li,
- Giulia Bastianello,
- Christopher Bruhn,
- Irene Giovannetti,
- Adhil Mohamood,
- Galina V. Beznoussenko,
- Alexandre Mironov,
- Matthew Raab,
- Matthieu Piel,
- Umberto Restuccia,
- Vittoria Matafora,
- Angela Bachi,
- Sara Barozzi,
- Dario Parazzoli,
- Emanuela Frittoli,
- Andrea Palamidessi,
- Tito Panciera,
- Stefano Piccolo,
- Giorgio Scita,
- Paolo Maiuri,
- Kristina M. Havas,
- Zhong-Wei Zhou,
- Amit Kumar,
- Jiri Bartek,
- Zhao-Qi Wang,
- Marco Foiani
Affiliations
- Gururaj Rao Kidiyoor
- IFOM- FIRC Institute of Molecular Oncology
- Qingsen Li
- IFOM- FIRC Institute of Molecular Oncology
- Giulia Bastianello
- IFOM- FIRC Institute of Molecular Oncology
- Christopher Bruhn
- IFOM- FIRC Institute of Molecular Oncology
- Irene Giovannetti
- IFOM- FIRC Institute of Molecular Oncology
- Adhil Mohamood
- IFOM- FIRC Institute of Molecular Oncology
- Galina V. Beznoussenko
- IFOM- FIRC Institute of Molecular Oncology
- Alexandre Mironov
- IFOM- FIRC Institute of Molecular Oncology
- Matthew Raab
- Institut Curie/CNRS
- Matthieu Piel
- Institut Curie/CNRS
- Umberto Restuccia
- IFOM- FIRC Institute of Molecular Oncology
- Vittoria Matafora
- IFOM- FIRC Institute of Molecular Oncology
- Angela Bachi
- IFOM- FIRC Institute of Molecular Oncology
- Sara Barozzi
- IFOM- FIRC Institute of Molecular Oncology
- Dario Parazzoli
- IFOM- FIRC Institute of Molecular Oncology
- Emanuela Frittoli
- IFOM- FIRC Institute of Molecular Oncology
- Andrea Palamidessi
- IFOM- FIRC Institute of Molecular Oncology
- Tito Panciera
- University of Padova
- Stefano Piccolo
- IFOM- FIRC Institute of Molecular Oncology
- Giorgio Scita
- IFOM- FIRC Institute of Molecular Oncology
- Paolo Maiuri
- IFOM- FIRC Institute of Molecular Oncology
- Kristina M. Havas
- IFOM- FIRC Institute of Molecular Oncology
- Zhong-Wei Zhou
- Leibniz Institute on Aging, Fritz Lipmann Institute
- Amit Kumar
- Genome and Cell Integrity Lab, CSIR-Indian Institute of Toxicology Research
- Jiri Bartek
- Danish Cancer Society Research Center
- Zhao-Qi Wang
- Leibniz Institute on Aging, Fritz Lipmann Institute
- Marco Foiani
- IFOM- FIRC Institute of Molecular Oncology
- DOI
- https://doi.org/10.1038/s41467-020-18580-9
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
The nucleus is a mechanically stiff organelle of the cell and the DNA damage response protein ATR can localize to the nuclear envelope upon mechanical stress. Here, the authors show that ATR may contribute to the integrity of the nuclear envelope and may play a role in cell migration.
