Nature Communications (Apr 2023)

The Trypanosoma cruzi Antigen and Epitope Atlas: antibody specificities in Chagas disease patients across the Americas

  • Alejandro D. Ricci,
  • Leonel Bracco,
  • Emir Salas-Sarduy,
  • Janine M. Ramsey,
  • Melissa S. Nolan,
  • M. Katie Lynn,
  • Jaime Altcheh,
  • Griselda E. Ballering,
  • Faustino Torrico,
  • Norival Kesper,
  • Juan C. Villar,
  • Iván S. Marcipar,
  • Jorge D. Marco,
  • Fernán Agüero

DOI
https://doi.org/10.1038/s41467-023-37522-9
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 18

Abstract

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This work reveals the diversity and extent of human antibody specificities in Chagas disease and provides a wealth of well-defined antigenic markers for diagnosis and development of serological applications for this neglected infectious disease.