Nature Communications (Dec 2022)

Chemoenzymatic synthesis of sulfur-linked sugar polymers as heparanase inhibitors

  • Peng He,
  • Xing Zhang,
  • Ke Xia,
  • Dixy E. Green,
  • Sultan Baytas,
  • Yongmei Xu,
  • Truong Pham,
  • Jian Liu,
  • Fuming Zhang,
  • Andrew Almond,
  • Robert J. Linhardt,
  • Paul L. DeAngelis

DOI
https://doi.org/10.1038/s41467-022-34788-3
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

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Heparin is a family of complex carbohydrates binding to proteins to modulate cell activities. Here the authors report the synthesis, and conformations simulations of S-linked hemi-A heparosan [GlcA-S-GlcNAc]n, a thio-glycosidic uncleavable polysaccharide, and test it as human heparanase inhibitor.