Nature Communications (Nov 2016)
tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence
Abstract
Mycobacteria can adapt to the stress of human infection by entering a dormant state. Here the authors show that hypoxia-induced dormancy in M. bovisBCG involves the reprogramming of tRNA wobble modifications and copy numbers, coupled with biased use of synonymous codons in survival genes.