Nature Communications (Nov 2016)

tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence

  • Yok Hian Chionh,
  • Megan McBee,
  • I. Ramesh Babu,
  • Fabian Hia,
  • Wenwei Lin,
  • Wei Zhao,
  • Jianshu Cao,
  • Agnieszka Dziergowska,
  • Andrzej Malkiewicz,
  • Thomas J. Begley,
  • Sylvie Alonso,
  • Peter C. Dedon

DOI
https://doi.org/10.1038/ncomms13302
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

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Mycobacteria can adapt to the stress of human infection by entering a dormant state. Here the authors show that hypoxia-induced dormancy in M. bovisBCG involves the reprogramming of tRNA wobble modifications and copy numbers, coupled with biased use of synonymous codons in survival genes.